Smoking a pack a day for a year causes 150 mutations in lung cells
Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory and their collaborators found smokers accumulated an average of 150 extra mutations in every lung cell for each year of smoking one packet of cigarettes a day.
Reported in the Journal Science, the study provides a direct link between the number of cigarettes smoked in a lifetime and the number of mutations in the tumour DNA. The highest mutation rates were seen in the lung cancers but tumours in other parts of the body also contained these smoking-associated mutations, explaining how smoking causes many types of human cancer. more

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The Human Genetics Foundation – Torino (HuGeF) is seeking a motivated person with significant theoretical and practical training and significant experience in flow cytometry and cell sorting to fill the position of Manager of its Flow Cytometry and Cell Sorting Facility. more
Upcoming paper on British Journal of Cancer
Bladder cancer (BC) is among the most common malignancies worldwide. In recent years, there has been an increased interest in the identification of new biomarkers for early BC detection and recurrence/progression.
In the study of Pardini, Viberti et al. the levels of chromosomal damage were evaluated in lymphocytes from 158 BC cases more
three-dimensional structure of RNA molecules
Thanks to the new sequencing technologies, it is now possible to define the three-dimensional structure of RNA molecules to understand their function.
A large fraction of the cellular DNA is transcribed into RNA molecules, which function either as a cellular message more
Identifying previously unrecognized, recurrently mutated genes
Next generation sequencing implemented our knowledge of chronic lymphocytic leukemia (CLL) mutational landscape by identifying previously unrecognized, recurrently mutated genes. Among others, mutations in the PEST domain of NOTCH1 more