A year of protein-protein interactions
Thousands of proteins are simultaneously expressed in a typical cell, and their concerted specific interactions regulate the large majority of cellular functions leading to healthy or diseased states. Two major questions are crucial for our understanding of the protein-protein interaction network (PPI): (1) who interacts with whom, and (2) how proteins interact at the structural molecular level. Thanks to the development of high-throughput sequencing machines, the size of genomic databases is exponentially increasing: more than 6,500 complete genomes have been sequenced to date and another 21,000 sequencing projects are currently in progress (GOLD database: http://genomesonline.org). As a result, the last census of the Uniprot database lists more than 80 million protein sequences (uniprot.org), with a 50% increase in the last year.

In a series of three paper published in 2016, we proposed a complex and reliable computational strategy to leverage this huge more
October 6, 2016
Critelli and colleagues on Oncotarget
Bladder cancer accounts for about 3% of all cancers and, in urology, is second only to prostate cancer. It is more common among those over 60 years old and is three times more common in men than in women. At diagnosis, the cancer is of the more
September 22, 2015
Synapses need only few bits
Deep learning is possibly the most exciting branch of contemporary machine learning. Complex image analysis, speech recognition and self-driving cars are just a few popular examples of a multitude of new applications where machine learning, and deep learning in particular, more.
June 12, 2015

The group of Genomic Variation published a paper
investigating the effects of cigarette smoke exposure on genomic DNA methylation in twins with discordant smoking habits...
February, 5 2015

A new paper from the Epigenetic Group
about the development of a new method to map at single base resolution the presence of 5-formylcytosine (5fC) and 5-carbxylcytosine (5caC) more