Smoking a pack a day for a year causes 150 mutations in lung cells
Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory and their collaborators found smokers accumulated an average of 150 extra mutations in every lung cell for each year of smoking one packet of cigarettes a day.
Reported in the Journal Science, the study provides a direct link between the number of cigarettes smoked in a lifetime and the number of mutations in the tumour DNA. The highest mutation rates were seen in the lung cancers but tumours in other parts of the body also contained these smoking-associated mutations, explaining how smoking causes many types of human cancer. more

A year of protein-protein interactions
Thousands of proteins are simultaneously expressed in a typical cell, and their concerted specific interactions regulate the large majority of cellular functions leading to healthy or diseased states. Two major questions are crucial for our understanding of the protein-protein interaction network (PPI) more
October 6, 2016
Critelli and colleagues on Oncotarget
Bladder cancer accounts for about 3% of all cancers and, in urology, is second only to prostate cancer. It is more common among those over 60 years old and is three times more common in men than in women. At diagnosis, the cancer is of the more
September 22, 2015
Synapses need only few bits
Deep learning is possibly the most exciting branch of contemporary machine learning. Complex image analysis, speech recognition and self-driving cars are just a few popular examples of a multitude of new applications where machine learning, and deep learning in particular, more.
June 12, 2015

The group of Genomic Variation published a paper
investigating the effects of cigarette smoke exposure on genomic DNA methylation in twins with discordant smoking habits...