Smoking a pack a day for a year causes 150 mutations in lung cells
Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory and their collaborators found smokers accumulated an average of 150 extra mutations in every lung cell for each year of smoking one packet of cigarettes a day.
Reported in the Journal Science, the study provides a direct link between the number of cigarettes smoked in a lifetime and the number of mutations in the tumour DNA. The highest mutation rates were seen in the lung cancers but tumours in other parts of the body also contained these smoking-associated mutations, explaining how smoking causes many types of human cancer. more

Upcoming paper on British Journal of Cancer
Bladder cancer (BC) is among the most common malignancies worldwide. In recent years, there has been an increased interest in the identification of new biomarkers for early BC detection and recurrence/progression.
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three-dimensional structure of RNA molecules
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A large fraction of the cellular DNA is transcribed into RNA molecules, which function either as a cellular message more
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Next generation sequencing implemented our knowledge of chronic lymphocytic leukemia (CLL) mutational landscape by identifying previously unrecognized, recurrently mutated genes. Among others, mutations in the PEST domain of NOTCH1 more
A year of protein-protein interactions
Thousands of proteins are simultaneously expressed in a typical cell, and their concerted specific interactions regulate the large majority of cellular functions leading to healthy or diseased states. Two major questions are crucial for our understanding of the protein-protein interaction network (PPI) more