HuGeF - Torino is a private not-for-profit institution. It was established in November 2007 by the Compagnia di San Paolo, the University of Turin and the Turin Polytechnic.
The Foundation aims at developing research of excellence and post-graduate training in the field of human genetics, genomics and proteomics; creating synergies with national and international projects and attracting talents along with the strengthening of local skills. The Foundation's laboratories started their activity in 2010.
The main goal of HuGeF - Torino is to foster and develop excellence in human genetic research and education, with special reference to genomic variability in multifactorial diseases.
Defining the functions of individual genes and understand their complex interactions is essential to unlock their role in health and disease. To successfully tackle this mission, HuGeF-Torino integrates – in a single facility and with an innovative organization model – molecular, cellular, developmental and population genetics, integrating theoretical approaches and state-of the art technological platforms.
A paper from the Statistical Inference and Computational Biology appears on PNAS
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments READ MORE
A paper by Davide Brusa et al. appears on Haematologogica
The PD-1/PD-L1 axis contributes to T cell dysfunction in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is marked by profound defects in T cell function. Programmed death-1 (PD-1) is a receptor involved in tumor-mediated immunosuppression through binding of the PD-L1 ligand. In this work Davide Brusa et al. showed that PD-1 expression by CD4+ and CD8+ T lymphocytes was significantly higher in CLL patients READ MORE
Article about Paolo Vineis project appears on Nature
Daily dose of toxics to be tracked
Exposome studies will tie environmental exposure to biological triggers of disease.Read the full article