EPIDEMIOLOGIA GENETICA E MOLECOLARE

1.Azar Sharabiani MT, Vermeulen R, Scoccianti C, Hosnijeh FS, Minelli L, Sacerdote C, Palli D, Krogh V, Tumino R, Chiodini P, Panico S, Vineis P. Immunologic profile of excessive body weight. Biomarkers. 2011 May;16(3):243-51.
2.Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; The International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS); CARDIoGRAM consortium; CKDGen consortium; KidneyGen consortium; EchoGen consortium; CHARGE-HF consortium, Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-2284. Epub 2011 Mar 4.

CONTINUA

VARIABILITA' GENOMICA DELLE POPOLAZIONI UMANE E MALATTIE COMPLESSE

1. Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr, Grubb R 3rd, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF Jr, Silverman DT, Chanock SJ. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010 Nov;42(11):978-84. Epub 2010 Oct 24. PubMed PMID: 20972438.
2. Mazzei F, Guarrera S, Allione A, Simonelli V, Narciso L, Barone F, Minoprio A, Ricceri F, Funaro A, D'Errico M, Vogel U, Matullo G, Dogliotti E. 8-Oxoguanine DNA-glycosylase repair activity and expression: A comparison between cryopreserved isolated lymphocytes and EBV-derived lymphoblastoid cell lines. Mutat Res. 2010 Nov 4. [Epub ahead of print] PubMed PMID: 20971211.
3. Ricceri F, Godschalk RW, Peluso M, Phillips D, Agudo A, Georgiadis PA, Loft S, Tjonneland AM, Raaschou-Nielsen O, Palli D, Perera F, Vermeulen R, Taioli E, Sram RJ, Munnia A, Rosa F, Allione A, Matullo G, Vineis PP. Bulky DNA adducts in white blood cells: a pooled analysis of 3600 subjects. Cancer Epidemiol Biomarkers Prev. 2010 Oct 4. [Epub ahead of print] PubMed PMID: 20921335.

GENETICA DEL SISTEMA IMMUNITARIO

LAVORI DI RICERCA
- Saborit-Villarroya, I., T. Vaisitti, D. Rossi, G. D'Arena, G. Gaidano, F. Malavasi, and S. Deaglio. 2011. E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia. Leukemia 25:479-488.
- Audrito, V., T. Vaisitti, D. Rossi, D. Gottardi, G. D'Arena, L. Laurenti, G. Gaidano, F. Malavasi, and S. Deaglio. 2011. Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer research 71:4473-4483.
- Ferretti, E., M. Bertolotto, S. Deaglio, C. Tripodo, D. Ribatti, V. Audrito, F. Blengio, S. Matis, S. Zupo, D. Rossi, L. Ottonello, G. Gaidano, F. Malavasi, V. Pistoia, and A. Corcione. 2011a. A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment. Leukemia:25:1268-1277.
- Rossi, D., S. Deaglio, D. Dominguez-Sola, S. Rasi, T. Vaisitti, C. Agostinelli, V. Spina, A. Bruscaggin, S. Monti, M. Cerri, S. Cresta, M. Fangazio, L. Arcaini, M. Lucioni, R. Marasca, C. Thieblemont, D. Capello, F. Facchetti, I. Kwee, S.A. Pileri, R. Foa, F. Bertoni, R. Dalla-Favera, L. Pasqualucci, and G. Gaidano. 2011. Alteration of BIRC3 and multiple other NF-{kappa}B pathway genes in splenic marginal zone lymphoma. Blood in press.
- Serra, S., A. Horenstein, V. T., D. Brusa, D. Rossi, L. Laurenti, G. D'Arena, M. Coscia, C. Tripodo, G. Inghirami, S.C. Robson, G. Gaidano, F. Malavasi, and D. S. 2011. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood in press. ( A paper from Silvia Deaglio's lab describes a novel autocrine loop that creates favorable microenvironmental conditions for growth and survival of chronic lymphocytic leukemia (CLL) cells.)

CONTINUA

EPIGENETICA

1.Galvagni, S. Pennacchini, A. Salameh, M. Rocchigiani, F. Neri, M. Orlandini, F. Petraglia, S. Gotta, G. L. Sardone, G. Matteucci, G. C. Terstappen, and S. Oliviero. Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity. 2010 Circulation Research 106:1839-184.
2.Salameh, F. Galvagni, F. Anselmi, C. De Clemente, M. Orlandini, and Salvatore Oliviero. Growth factor stimulation induces cell survival by c-JUN/ATF2-dependent activation of BCL-XL. Journal of Biological Chemistry 2010 285 :23096-23104.
3.Francesco Neri, Alessio Zippo, Anna Krepelova, Alessandro Cherubini, Marina Rocchigiani, and Salvatore Oliviero. Myc regulates the expression of PRC2 to maintain pluripotency of embryonic stem cells. Submitted to Genes and Development.
4.Federico Galvagni, Sandrine Evellin, Alessio Zippo, Francesco Neri, and Salvatore Oliviero. FOSL1 induces cell mobility by negative regulation of integrins. Submitted to Journal of Biological Chemistry.

INFERENZA STATISTICA E BIOLOGIA COMPUTAZIONALE

1. M. Bailly-Bechet, A. Braunstein, A. Pagnani, M.Weigt, and R. Zecchina, "Inference of sparse combinatorial-control networks from gene-expression data: a message passing approach", BMC Bioinformatics 11:355 (2010).
2. A. Pagnani and M. Pretti, "A discrete model of water with two distinct glassy phases", EPL, 92:4, 46008 (2010).
3. Bailly-Bechet M, Borgs C, Braunstein A, Chayes J, Dagkessamanskaia A, François JM, R. Zecchina. Finding undetected protein associations in cell signaling by belief propagation. Proceedings of the National Academy of Sciences 108 (2) 882-887 (2010).
4. M. Bailly-Bechet, A. Benecke, W.D. Hard, V. Lanza, A. Sturm, R. Zecchina, «An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium», Journal of Mathematical Biology, (2010).
5. F. Altarelli, A. Braunstein, A. Ramezanpour, and R. Zecchina, Stochastic matching problem, to app. In Phys. Rev. Lett. (2011).
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8. A. Procaccini, B. Lunt, H. Szurmant, T. Hwa, M. Weigt, Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalk, to app. In PLoS ONE (2011).